The one tricky part has been replacing Word or WordPad as my note taker. When you've got to copy down someone's address from an email and you need a temporary place to store it while you do other things, or when beloved readers leave captcha words in their comments for Jacob to turn into captchadefs, where do you put them?
I'm just starting to use Dreamweaver to do that. When you think about it, Dreamweaver can do almost everything Word can do, short of organizing things in a document with tables of contents. As I understand it, InDesign can do that part. Unfortunately, InDesign is a bit more difficult to use than Word (at least so far for me), but Dreamweaver does an outstanding job as a note taker. The files are much smaller and whatever I create there is ready for cut and paste onto a blog without having to worry that it's encrusted with formatting tags like MS Word snippets.
My initial take on this experiment is that it will be a big success. Dreamweaver replaces Word just fine.